The beginning of the trailer starts off with someone asking for the safe return of their daughter (which is likely the start of your Far Harbor questline), and being the good samaritan/ruthless mercenary that you are, you decide to get on a boat and look for their daughter (what can possibly go wrong?). Speaking of Point Lookout, there is a distinct possibility that Far Harbor may borrow some plot points from the last time Bethesda had a DLC that was based on swamps and cults. Totally safe place where nothing's going to kill you Conversely, this might also make fighting in Far Harbor one of the most graphically pleasing and or frustrating things in Fallout 4, at least if prior experiences in Fallout 3's Point Lookout DLC is any indicator.
Naturally, this would probably make long range weapons less effective, mostly due to the fact that you can't really snipe someone if you can't see them through thick radioactive fog. This means that the usual buildings, streets, and baseball stadiums that you fought in will be replaced by small fishing towns, swamps, and forests. The most obvious difference between the Commonwealth wasteland and Far Harbor is that it simply is a geographically different place. It's totally not like Point Lookout at all!
